Review



hcn2  (Cell Signaling Technology Inc)


Bioz Verified Symbol Cell Signaling Technology Inc is a verified supplier
Bioz Manufacturer Symbol Cell Signaling Technology Inc manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 93
      Buy from Supplier

    Structured Review

    Cell Signaling Technology Inc hcn2
    Hcn2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hcn2/HCN2+Rabbit+mAb/pm40914319-99-12-13
    Average 93 stars, based on 11 article reviews
    hcn2 - by Bioz Stars, 2026-10
    93/100 stars

    Images

    Related Articles

    Expressing:

    Article Title: The role of HCN channels on the effects of T-type calcium channels and GABA A receptors in the absence epilepsy model of WAG/Rij rats.
    Article Snippet: In this study we used ivabradine (IVA), a hyperpolarization-activated cyclic nucleotide–gated (HCN) channel blocker, to identify its effect on spike-wave discharges (SWDs); and aimed to determine the role of IVA on the effects of T-type calcium channel blocker NNC 55-0396, GABAA receptor agonist muscimol and antagonist bicuculline in male WAG/Rij rats.. After tripolar electrodes for electrocorticogram (ECoG) recordings were placed on the WAG/Rij rats' skulls, 5, 10, and 20 mg/ kg IVA were intraperitoneally administered for 7 consecutive days and ECoG recordings were obtained on days 0th, 3rd, 6th, and 7th for three hours before and after injections.. While acute injection of 5, 10, and 20 mg/kg IVA did not affect the total number and the mean duration of SWDs, subacute administration (7 days) of IVA decreased the SWDs parameters 24 hours after the 7th injection.

    Isolation:

    Article Title: The role of HCN channels on the effects of T-type calcium channels and GABA A receptors in the absence epilepsy model of WAG/Rij rats.
    Article Snippet: In this study we used ivabradine (IVA), a hyperpolarization-activated cyclic nucleotide–gated (HCN) channel blocker, to identify its effect on spike-wave discharges (SWDs); and aimed to determine the role of IVA on the effects of T-type calcium channel blocker NNC 55-0396, GABAA receptor agonist muscimol and antagonist bicuculline in male WAG/Rij rats.. After tripolar electrodes for electrocorticogram (ECoG) recordings were placed on the WAG/Rij rats' skulls, 5, 10, and 20 mg/ kg IVA were intraperitoneally administered for 7 consecutive days and ECoG recordings were obtained on days 0th, 3rd, 6th, and 7th for three hours before and after injections.. While acute injection of 5, 10, and 20 mg/kg IVA did not affect the total number and the mean duration of SWDs, subacute administration (7 days) of IVA decreased the SWDs parameters 24 hours after the 7th injection.

    Western Blot:

    Article Title: The role of HCN channels on the effects of T-type calcium channels and GABA A receptors in the absence epilepsy model of WAG/Rij rats.
    Article Snippet: In this study we used ivabradine (IVA), a hyperpolarization-activated cyclic nucleotide–gated (HCN) channel blocker, to identify its effect on spike-wave discharges (SWDs); and aimed to determine the role of IVA on the effects of T-type calcium channel blocker NNC 55-0396, GABAA receptor agonist muscimol and antagonist bicuculline in male WAG/Rij rats.. After tripolar electrodes for electrocorticogram (ECoG) recordings were placed on the WAG/Rij rats' skulls, 5, 10, and 20 mg/ kg IVA were intraperitoneally administered for 7 consecutive days and ECoG recordings were obtained on days 0th, 3rd, 6th, and 7th for three hours before and after injections.. While acute injection of 5, 10, and 20 mg/kg IVA did not affect the total number and the mean duration of SWDs, subacute administration (7 days) of IVA decreased the SWDs parameters 24 hours after the 7th injection.

    Article Title: HCN2 promotes neurodevelopmental and synaptic function repair through the CaMKII/CREB pathway to alleviate general anesthesia-induced cognitive impairment.
    Article Snippet: Repeated exposure to gestational general anesthesia during pregnancy has been associated with neurodevelopmental damage and cognitive and social dysfunction in offspring.. This study investigates the underlying mechanisms and therapeutic strategies for mitigating these effects.. Behavioral tests revealed significant impairments in cognitive, social, and spatial learning abilities in the offspring of general anesthesia-treated mice, alongside delayed eye-opening, reduced body weight, and neuronal damage.

    Construct:

    Article Title: The role of bFGF in preventing the shrinkage of cardiac progenitor cell-engineered conduction tissue by downregulating α-SMA expression.
    Article Snippet: Aims: Engineered conduction tissues (ECTs) fabricated from cardiac progenitor cells (CPCs) and collagen sponges were precisely targeted for the treatment of atrioventricular conduction block in our previous studies.. However, obvious shrinkage and deformation of ECTs was observed during in vitro culture.. According to the literature, it can be speculated that basic fibroblast growth factor (bFGF) may downregulate alpha-smooth muscle actin (α-SMA) produced by CPCs to prevent the shrinkage of CPC-engineered conduction tissues.

    Incubation:

    Article Title: The role of bFGF in preventing the shrinkage of cardiac progenitor cell-engineered conduction tissue by downregulating α-SMA expression.
    Article Snippet: Aims: Engineered conduction tissues (ECTs) fabricated from cardiac progenitor cells (CPCs) and collagen sponges were precisely targeted for the treatment of atrioventricular conduction block in our previous studies.. However, obvious shrinkage and deformation of ECTs was observed during in vitro culture.. According to the literature, it can be speculated that basic fibroblast growth factor (bFGF) may downregulate alpha-smooth muscle actin (α-SMA) produced by CPCs to prevent the shrinkage of CPC-engineered conduction tissues.

    Cell-Signaling:

    Article Title: Alterations in SUMOylation of the hyperpolarization‐activated cyclic nucleotide‐gated ion channel 2 during persistent inflammation
    Article Snippet: .. Each set was probed with a different antibody that recognized HCN2, SUMO1 (Cell Signaling, 4930S, 1:1,500) or SUMO2/3 (Abcam, ab3742, 1:750). .. Blots were washed 3× for 5 min in TTBS and then incubated with goat anti‐rabbit alkaline phosphatase conjugated secondary antibody (Jackson ImmunoResearch, 1:4,000), prepared in 1% non‐fat dry milk in TTBS, for 2 hr with agitation at RT.



    Similar Products

    anti hcn2  (Arigo Biolaboratories)
    86
    Arigo Biolaboratories anti hcn2
    Anti Hcn2, supplied by Arigo Biolaboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hcn2/anti+hcn2/pm41872392-30-49-51
    Average 86 stars, based on 1 article reviews
    anti hcn2 - by Bioz Stars, 2026-10
    86/100 stars
    		  Buy from Supplier
    anti hcn2  (NeuroMab)
    94
    NeuroMab anti hcn2
    Anti Hcn2, supplied by NeuroMab, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hcn2/Anti-HCN2+Antibody/pm41689161-100-10-20
    Average 94 stars, based on 1 article reviews
    anti hcn2 - by Bioz Stars, 2026-10
    94/100 stars
    		  Buy from Supplier
    hcn2  (NeuroMab)
    94
    NeuroMab hcn2
    HCN, an I h ion channel, localized to both inner and outer surfaces of calyces. (A) Section from the CZ of a female rat crista immunolabeled for calretinin ( Calret , green ) and <t>HCN2</t> (red) in several calretinin‐positive calyx‐only afferents; a single calretinin‐negative dimorphic calyx ( D ) is present. In (A’), the calretinin label seen in (A) has been removed to show light HCN2 labeling of all calyces, including the dimorphic calyx ending. (B, B’) Same immunolabeling as in (A, A’), but from the PZ. A single type II hair cell ( II ) and several dimorphic ( D ) calyces are present; the calyces are slightly more heavily labeled for HCN2 than are those in the CZ; the type II hair cell is very lightly HCN2 labeled. HCN2 label is found on both the inner and outer surfaces of the calyx ( arrows ). Scale bar (for all four panels) = 5 µm.
    Hcn2, supplied by NeuroMab, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hcn2/Anti-HCN2+Antibody/pmc12852067-27-0-2
    Average 94 stars, based on 1 article reviews
    hcn2 - by Bioz Stars, 2026-10
    94/100 stars
    		  Buy from Supplier
    anti hcn2  (Proteintech)
    93
    Proteintech anti hcn2
    HCN, an I h ion channel, localized to both inner and outer surfaces of calyces. (A) Section from the CZ of a female rat crista immunolabeled for calretinin ( Calret , green ) and <t>HCN2</t> (red) in several calretinin‐positive calyx‐only afferents; a single calretinin‐negative dimorphic calyx ( D ) is present. In (A’), the calretinin label seen in (A) has been removed to show light HCN2 labeling of all calyces, including the dimorphic calyx ending. (B, B’) Same immunolabeling as in (A, A’), but from the PZ. A single type II hair cell ( II ) and several dimorphic ( D ) calyces are present; the calyces are slightly more heavily labeled for HCN2 than are those in the CZ; the type II hair cell is very lightly HCN2 labeled. HCN2 label is found on both the inner and outer surfaces of the calyx ( arrows ). Scale bar (for all four panels) = 5 µm.
    Anti Hcn2, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hcn2/HCN2+Antibody/pm41258586-99-9-11
    Average 93 stars, based on 1 article reviews
    anti hcn2 - by Bioz Stars, 2026-10
    93/100 stars
    		  Buy from Supplier
    hcn2  (Cell Signaling Technology Inc)
    93
    Cell Signaling Technology Inc hcn2
    HCN, an I h ion channel, localized to both inner and outer surfaces of calyces. (A) Section from the CZ of a female rat crista immunolabeled for calretinin ( Calret , green ) and <t>HCN2</t> (red) in several calretinin‐positive calyx‐only afferents; a single calretinin‐negative dimorphic calyx ( D ) is present. In (A’), the calretinin label seen in (A) has been removed to show light HCN2 labeling of all calyces, including the dimorphic calyx ending. (B, B’) Same immunolabeling as in (A, A’), but from the PZ. A single type II hair cell ( II ) and several dimorphic ( D ) calyces are present; the calyces are slightly more heavily labeled for HCN2 than are those in the CZ; the type II hair cell is very lightly HCN2 labeled. HCN2 label is found on both the inner and outer surfaces of the calyx ( arrows ). Scale bar (for all four panels) = 5 µm.
    Hcn2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hcn2/HCN2+Rabbit+mAb/pm40914319-99-12-13
    Average 93 stars, based on 1 article reviews
    hcn2 - by Bioz Stars, 2026-10
    93/100 stars
    		  Buy from Supplier
    hcn2  (Proteintech)
    93
    Proteintech hcn2
    HCN, an I h ion channel, localized to both inner and outer surfaces of calyces. (A) Section from the CZ of a female rat crista immunolabeled for calretinin ( Calret , green ) and <t>HCN2</t> (red) in several calretinin‐positive calyx‐only afferents; a single calretinin‐negative dimorphic calyx ( D ) is present. In (A’), the calretinin label seen in (A) has been removed to show light HCN2 labeling of all calyces, including the dimorphic calyx ending. (B, B’) Same immunolabeling as in (A, A’), but from the PZ. A single type II hair cell ( II ) and several dimorphic ( D ) calyces are present; the calyces are slightly more heavily labeled for HCN2 than are those in the CZ; the type II hair cell is very lightly HCN2 labeled. HCN2 label is found on both the inner and outer surfaces of the calyx ( arrows ). Scale bar (for all four panels) = 5 µm.
    Hcn2, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hcn2/HCN2+Antibody/pm40775068-154-7-8
    Average 93 stars, based on 1 article reviews
    hcn2 - by Bioz Stars, 2026-10
    93/100 stars
    		  Buy from Supplier
    anti hcn2  (Alomone Labs)
    94
    Alomone Labs anti hcn2
    HCN, an I h ion channel, localized to both inner and outer surfaces of calyces. (A) Section from the CZ of a female rat crista immunolabeled for calretinin ( Calret , green ) and <t>HCN2</t> (red) in several calretinin‐positive calyx‐only afferents; a single calretinin‐negative dimorphic calyx ( D ) is present. In (A’), the calretinin label seen in (A) has been removed to show light HCN2 labeling of all calyces, including the dimorphic calyx ending. (B, B’) Same immunolabeling as in (A, A’), but from the PZ. A single type II hair cell ( II ) and several dimorphic ( D ) calyces are present; the calyces are slightly more heavily labeled for HCN2 than are those in the CZ; the type II hair cell is very lightly HCN2 labeled. HCN2 label is found on both the inner and outer surfaces of the calyx ( arrows ). Scale bar (for all four panels) = 5 µm.
    Anti Hcn2, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hcn2/Anti-HCN2+Antibody/pm40764992-92-24-26
    Average 94 stars, based on 1 article reviews
    anti hcn2 - by Bioz Stars, 2026-10
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    HCN, an I h ion channel, localized to both inner and outer surfaces of calyces. (A) Section from the CZ of a female rat crista immunolabeled for calretinin ( Calret , green ) and HCN2 (red) in several calretinin‐positive calyx‐only afferents; a single calretinin‐negative dimorphic calyx ( D ) is present. In (A’), the calretinin label seen in (A) has been removed to show light HCN2 labeling of all calyces, including the dimorphic calyx ending. (B, B’) Same immunolabeling as in (A, A’), but from the PZ. A single type II hair cell ( II ) and several dimorphic ( D ) calyces are present; the calyces are slightly more heavily labeled for HCN2 than are those in the CZ; the type II hair cell is very lightly HCN2 labeled. HCN2 label is found on both the inner and outer surfaces of the calyx ( arrows ). Scale bar (for all four panels) = 5 µm.

    Journal: The Journal of Comparative Neurology

    Article Title: Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment

    doi: 10.1002/cne.70127

    Figure Lengend Snippet: HCN, an I h ion channel, localized to both inner and outer surfaces of calyces. (A) Section from the CZ of a female rat crista immunolabeled for calretinin ( Calret , green ) and HCN2 (red) in several calretinin‐positive calyx‐only afferents; a single calretinin‐negative dimorphic calyx ( D ) is present. In (A’), the calretinin label seen in (A) has been removed to show light HCN2 labeling of all calyces, including the dimorphic calyx ending. (B, B’) Same immunolabeling as in (A, A’), but from the PZ. A single type II hair cell ( II ) and several dimorphic ( D ) calyces are present; the calyces are slightly more heavily labeled for HCN2 than are those in the CZ; the type II hair cell is very lightly HCN2 labeled. HCN2 label is found on both the inner and outer surfaces of the calyx ( arrows ). Scale bar (for all four panels) = 5 µm.

    Article Snippet: HCN2 , NeuroMab , 75‐111 RRID:AB_2279449 , , , , , , Datasheet.

    Techniques: Immunolabeling, Labeling